Folliq Lab

What it does:
Derived from a rare Swiss apple variety (Uttwiler Spätlauber), these stem cells are rich in epigenetic factors and metabolites that help protect human follicle cells from oxidative stress and premature ageing — preserving their function longer.

Supporting evidence:

• In vitro studies show the extract can help maintain vitality and proliferation of dermal stem cells by 80–100% longer under oxidative stress.
• Cosmetic studies report improvement in scalp skin condition and delayed hair follicle regression.
• Though not a direct growth stimulant, it helps preserve the environment needed for growth.

What it does:
AnaGain™ is a patented extract derived from young organic pea sprouts. It works by reactivating dermal papilla cells at the base of the follicle — the cells responsible for hair growth signalling. This helps extend the growth phase and delay the shedding phase of the hair cycle.

Supporting evidence:

• A clinical study by Mibelle Biochemistry showed that AnaGain™ increased hair density by 78% in three months, based on phototrichogram analysis of volunteers.
• Gene expression profiling found upregulation of key signalling molecules: Noggin and FGF7 — associated with prolonging the anagen phase.

What it does:
Redensyl™ is a blend of four compounds that target the hair follicle’s stem cells and fibroblasts. It combines dihydroquercetin-glucoside (DHQG) with EGCG-glucoside, zinc, and glycine to help activate ORSc stem cells and support keratinocyte proliferation — essential for growth.

Supporting evidence:

• In a 2014 in vivo study, Redensyl™ led to +10,200 new hairs in 3 months when used twice daily vs placebo.
• 85% of participants reported visible improvement in hair density.
• Clinically shown to perform better than Minoxidil in one comparative trial over 3 months (see Induchem study).

Capilia Longa™ is a patented turmeric-based extract standardised to support epigenetic reactivation of hair follicle function. It helps reduce inflammation, downregulate hair loss markers, and revitalise the extracellular matrix around the follicle — key for anchoring hair securely.

Supporting evidence:

• Clinical trials showed 89% improvement in hair density and 52% reduction in hair fall within 150 days.
• Works by reprogramming the activity of over 1500 genes related to hair loss and regeneration.
• Also supports collagen remodelling, which is vital for follicle support.

What it does:
Saw Palmetto is a natural plant extract shown to inhibit 5-alpha reductase, the enzyme that converts testosterone into DHT. By reducing DHT levels in the scalp, it may help slow shedding and promote a healthier follicle environment for sustained growth.

Supporting evidence:

• A 2012 study published in The Journal of Alternative and Complementary Medicine found that men using topical Saw Palmetto experienced a 35% increase in hair density after 24 weeks.
• Another study in Evidence-Based Complementary and Alternative Medicine (2016) reported significant improvement in hair counts for participants using 5% topical Saw Palmetto lotion.
• It’s widely recognised as a gentler, natural alternative to finasteride — without the hormonal side effects.

What it does:
Caffeine isn’t just a stimulant for your brain — it also stimulates the hair follicle. Studies show it can counteract the effects of DHT, promote blood flow to the scalp, and extend the active growth phase (anagen) of the hair cycle.

Supporting evidence:

• A landmark 2007 International Journal of Dermatology study found that caffeine stimulates hair shaft elongation in vitro by promoting keratinocyte proliferation in male scalp biopsies.
• It’s been shown to penetrate the scalp barrier within 2 minutes of application, making it ideal in topical formulas.
• Regular topical use may improve follicle vitality and scalp blood circulation.

Biotin (Vitamin B7)

What it does:
Biotin is essential for the production of keratin, the key protein that forms hair. It supports stronger strands by improving hair cortex structure, reducing breakage, and supporting consistent growth in individuals with biotin deficiency.

Supporting evidence:

• A 2017 Skin Appendage Disorders review concluded that biotin supplementation benefits those with deficiency-related hair thinning, though topical use may also support scalp keratin production.
• Biotin improves keratin infrastructure and is widely used in hair repair products.
  

Niacinamide (Vitamin B3)

What it does:
Niacinamide supports microcirculation in the scalp and plays a vital role in cellular energy production (NAD+ pathway). It also helps balance oil production, soothe inflammation, and maintain the skin barrier.

Supporting evidence:

• Research shows Niacinamide improves vascularisation and oxygen supply to the hair follicle.
• A 2005 study found it beneficial in reducing inflammation and oxidative stress, which can contribute to hair thinning.
• Often used in dermatological treatments for seborrheic dermatitis and scalp irritation.
  

Panthenol (Vitamin B5)

What it does:
Panthenol is a humectant and pro-vitamin that deeply hydrates the scalp, reduces irritation, and strengthens the hair shaft by binding to keratin.

Supporting evidence:

• Known to improve hair thickness, softness, and elasticity when applied topically.
• Forms a thin protective film along hair strands that retains moisture and prevents damage.
• Though not a direct growth stimulant, it supports optimal scalp conditions needed for growth.

Aloe Vera (Aloe Barbadensis Leaf Juice)

Aloe Vera is a soothing botanical known for its hydrating, anti-inflammatory, and antimicrobial properties. It helps reduce scalp irritation, promote wound healing, and support a healthy follicular environment.

Supporting evidence:

• Studies confirm Aloe Vera’s ability to reduce itching, redness, and inflammation of the scalp.
• Contains compounds like glucomannan and gibberellins that may aid in skin cell regeneration and microcirculation.
• Commonly used to relieve symptoms of seborrheic dermatitis and scalp psoriasis.
  

Sodium Hyaluronate (Hyaluronic Acid)

What it does:
A salt form of hyaluronic acid, this ultra-hydrating molecule binds up to 1,000x its weight in water, making it ideal for scalp hydration. It improves comfort, reduces dryness, and strengthens the skin’s barrier — helping to maintain optimal follicular conditions.

Supporting evidence:

• Helps increase stratum corneum hydration, reducing inflammation and tightness on the scalp.
• Clinical studies show it improves trans-epidermal water loss and skin elasticity.
• Often used to prepare the scalp for better active ingredient penetration.